Purpose: Human malignant pleural mesothelioma (MPM) is characterized by dismal prognosis. Consequently, dissection of molecular mechanisms driving malignancy is of key importance. Here we investigate, whether activating mutations in the telomerase reverse transcriptase (TERT) gene promoter are present in MPM and associated with disease progression, … [Read more...]
Clinical Practice Guidelines for the Management of Malignant Pleural Mesothelioma
Clinical practice guidelines for the management of malignant pleural mesothelioma were released in May 2020 by the European Respiratory Society, European Society of Thoracic Surgeons, European Association for Cardio-Thoracic Surgery, and European Society for Radiotherapy and Oncology. Epidemiology Research Priorities The task force … [Read more...]
Nivolumab/Ipilimumab Demonstrates Durable OS Benefit in Malignant Pleural Mesothelioma
[ A nivolumab plus ipilimumab combination ] significantly improved overall survival (OS) versus chemotherapy in the first-line treatment of patients with unresectable malignant pleural mesothelioma, according to findings from a prespecified analysis of the phase 3 CheckMate-743 trial (NCT02899299) that were presented during the 2020 International … [Read more...]
Private Settlement Reached in Mesothelioma Case
A private settlement was reached in a mass litigation asbestos case [on July 28, 2020] in Ohio County [(West Virginia)] Circuit Court, meaning a trial set to take place at The Highlands Event Center next week won’t be necessary. Both Ohio County Clerk of Courts Brenda Miller and court employees for Judge Ronald Wilson said details of the … [Read more...]
Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis
Introduction: The prognostic role of BRCA1 associated protein-1 (BAP1) expression in malignant pleural mesothelioma (MPM) is a matter of debate. We aimed to clarify whether MPM patients with loss of BAP1 expression have better overall survival (OS) compared to BAP1 positive patients. Methods: [ BRCA1 associated protein-1 (BAP1) ] … [Read more...]
Study finds drug beneficial for shrinking mesothelioma tumors
A drug that is designed to boost the immune system against mesothelioma, when combined with immunotherapy, was found to be beneficial in a small study involving ten patients. The results, which appeared July 1, 2020, in Science Translational Medicine, suggest that the drug LMB-100 could prolong the life of some patients with advanced … [Read more...]