Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically is associated with short survival. CD70 and CD27 belong to the tumour necrosis factor (TNF) and the TNF receptor (TNFR) superfamily, respectively. Under physiological conditions, the tightly regulated interaction between CD70 and CD27 plays a … [Read more...]
Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications
Introduction: We compared the secretome of metastatic (non-small cell lung cancer (NSCLC)) and primary (mesothelioma) malignant pleural effusions, benign effusions and the published plasma profile of patients receiving chimeric antigen receptor T cells (CAR-T), to determine factors unique to neoplasia in pleural effusion (PE) and those accompanying … [Read more...]
STELLAR shows potential of tumor treating fields in mesothelioma
Combining tumor treating fields (TTFields) with standard chemotherapy could be a promising option for the first-line treatment of inoperable malignant pleural mesothelioma, say the STELLAR investigators. They explain in The Lancet Oncology that TTFields are “a non-invasive, regional, antimitotic treatment for solid tumours, that is based on the … [Read more...]
Recall: FDA Sees Trace Asbestos in J&J Baby Powder
A shipment of baby powder has been recalled by Johnson & Johnson after U.S. authorities found asbestos in it. The recall comes after months of denial from the company about the presence of the cancer-causing substance in its talc-based products, The New York Times reported [October 19, 2019]. But the U.S. Food and Drug Administration … [Read more...]
Survival results in biphasic malignant pleural mesothelioma patients: A multicentric analysis
Objective: The best strategy of care for biphasic malignant pleural mesothelioma (Biph-MPM) is controversial. In this study, a large dataset of Biph-MPM cases was reviewed to identify prognostic factors and to evaluate the role of a multimodal approach, including cancer-directed surgery. Methods: A total of 213 patients with Biph-MPM treated … [Read more...]
Intracavitary cisplatin-fibrin chemotherapy after surgery for malignant pleural mesothelioma: A phase I trial
Objectives: Intracavitary chemotherapy is a promising concept to improve local tumor control for malignant pleural mesothelioma with reported high morbidity rates. We have demonstrated that administration of cisplatin loaded to fibrin increased local drug concentration and reduced systemic toxicity in preclinical models. We present a phase I trial … [Read more...]