Adding bevacizumab (Avastin) to a standard chemotherapy doublet reduced the risk of death by 24% and disease progression by 39% in patients with malignant pleural mesothelioma (MPM), according to results from the phase II/III MAPS trial presented at the 2015 World Conference on Lung Cancer.
“The treatment of pemetrexed, cisplatin, and bevacizumab is a new treatment paradigm for patients with malignant pleural mesothelioma,” lead author Arnaud Scherpereel, MD, PhD, head of the Pulmonary and Thoracic Oncology Department and professor at the University Hospital (CHU) of Lille, France, said in a press conference at the World Lung meeting.
The French Cooperative Thoracic Intergroup (IFCT) phase II/III IFCT-GFPC-0701 MAPS trial included 448 chemotherapy-naïve patients enrolled across 73 locations between February 2008 and January 2014. Patients had to have unresectable, histologically confirmed MPM and an ECOG performance status (PS) of 0 to 2 (96.7% had a PS of 0-1). The median patient age was 65.7 years (range, 34.7-75.9).
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