The addition of nintedanib to pemetrexed/cisplatin appeared safe and effective for the treatment of patients with malignant pleural mesothelioma, according to results from the LUME-Meso trial presented at International Association for the Study of Lung Cancer Multidisciplinary Symposium in Thoracic Oncology. Nintedanib (Ofev, Boehringer Ingelheim) … [Read more...]
Nintedanib Chemo Combo Promising for Malignant Mesothelioma
Frontline treatment with nintedanib plus pemetrexed and cisplatin improved progression-free survival (PFS) by 3.7 months for chemotherapy-naive patients with malignant pleural mesothelioma (MPM), according to data reported at the 2017 ASCO Annual Meeting. In the phase II trial, known as LUME-Meso, the median PFS was 9.4 months with the nintedanib … [Read more...]
Bevacizumab for Newly Diagnosed Malignant Pleural Mesothelioma
Adding bevacizumab to cisplatin and pemetrexed improves survival, but at a cost of higher toxicity. Malignant pleural mesothelioma (MPM) is a challenging disease with few treatment options. In chemo-naive patients, pemetrexed plus a platinum agent remains the standard of care. To determine the potential benefit of adding … [Read more...]
Medical Study Of Amatuximab Plus Pemetrexed And Cisplatin In Patients With Unresectable Malignant Pleural Mesothelioma Shows Positive Results
This recent article, "Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma", initially published online in September 2014 by the Clinical Cancer Research medical journal, informs about an apparent advancement made in the treatment on malignant pleural … [Read more...]
Pemetrexed and Cisplatin Show Promise As Mesothelioma Treatment
Investigators announced the findings from phase 3 studies, which found that cisplatin plus an antifolate — either pemetrexed or raltitrexed — increase survival in patients with mesothelioma nearly 3-fold. The latest findings from a number of trials were announced at the European Respiratory Society 2008 Annual Congress by Thierry Berghmans, … [Read more...]
Lung Cancer Trial Uses Chemo-Radiation Therapy for Pleural Mesothelioma
Posted on AsbestosHUB. Patients are being recruited for a clinical trial of a new targeted radiation and chemotherapy protocol for pleural mesothelioma, a cancer of the lung's lining that's almost always caused by exposure to asbestos. Currently, the standard treatment is to remove the affected lung. "Current surgical and chemotherapy … [Read more...]