Pleural malignant mesothelioma in dental laboratory technicians: A case series

Asbestos was used in dentistry as a binder in periodontal dressings and as lining material for casting rings and crucible. However, until now, only one case of malignant mesothelioma with occupational exposure to asbestos in dental practice has been reported. We present 4 pleural mesotheliomas out of 5344 cases identified in Lombardy, Italy, in 2000-2014. Three men had been working as dental laboratory technicians, with asbestos exposure for 10, 34, and 4 years, and one woman had been helping her husband for 30 years in manufacturing dental prostheses. The men described the use of asbestos as a lining material for casting rings, while the woman was not able to confirm this use. We confirm the association of malignant mesothelioma with dental technician work. Dental technicians suffering from mesothelioma should be questioned about past occupational asbestos exposure.

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Source: Pleural malignant mesothelioma in dental laboratory technicians: A case series


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Malignant mesothelioma due to asbestos exposure in dental tape

Although most cases of malignant mesothelioma of the pleura are caused by one or more readily recognized sources of exposure to asbestos, cases of the disease with more occult exposure occur, especially since asbestos has been used in over 3,000 products. Dental lining tape contained asbestos from the 1930s until at least the 1970s and was used in the lost wax method of casting crowns, bridges, and other metal dental prosthetic devices. We report six cases of pathology-verified malignant mesothelioma, mostly among dentists, following exposure to airborne dust from asbestos dental tape, which resulted in asbestos tort litigation. According to evidence available at present, chrysotile asbestos was the type of asbestos used in dental tape in the past in the United States, and the described cases followed relatively brief and intermittent exposure to this type of asbestos. These cases underscore the need for comprehensive exposure histories to determine exposure scenarios.

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Source: Malignant mesothelioma due to asbestos exposure in dental tape


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Asbestos exposure is still making people sick

Researchers at the US Centers for Disease Control and Prevention are struggling to understand why younger populations continue to suffer asbestos-related medical issues despite efforts to reduce exposure from the toxic mineral.

According to a report released by the CDC on Thursday, numbers of deaths related to malignant mesothelioma increased from 2,479 in 1999 to 2,597 in 2015.

The largest increase was seen in those over 85 years old, but younger populations continue to be affected.

In those 16 years, 16,914 of the deaths were among people 75 to 84 years old. In the same period, 682 people between the ages of 25 and 44 died of mesothelioma-related problems.

“Although deaths among persons aged less than 35 years are of concern, we do not have information to understand potential causes,” said Dr. Jacek Mazurek, lead author of the CDC report.

Source: Asbestos exposure is still making people sick


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Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma (DIAPHRAGM) study: protocol of a prospective, multicentre, observational study

Malignant pleural mesothelioma (MPM) is an asbestos-related cancer, which is difficult to diagnose. Thoracoscopy is frequently required but is not widely available. An accurate, non-invasive diagnostic biomarker would allow early specialist referral, limit diagnostic delays and maximise clinical trial access. Current markers offer insufficient sensitivity and are not routinely used. The SOMAmer proteomic classifier and fibulin-3 have recently demonstrated sensitivity and specificity exceeding 90% in retrospective studies. DIAPHRAGM (Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma) is a suitably powered, multicentre, prospective observational study designed to determine whether these markers provide clinically useful diagnostic and prognostic information.

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Source: Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma (DIAPHRAGM) study: protocol of a prospective, multicentre, observational study


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Lung-sparing surgery may boost mesothelioma survival

Surgery that preserves the lung, when combined with other therapies, appears to extend the lives of people with a subtype of the rare and deadly cancer mesothelioma, a new study suggests.

Tracking 73 patients with advanced malignant pleural mesothelioma—which affects the lungs’ protective lining in the chest cavity—researchers found that those treated with lung-sparing had an average survival of nearly three years. A subset of those patients survived longer than seven years.

Mesothelioma patients treated with chemotherapy alone, which is standard care, live an average of 12 to 18 months, the researchers said.

Study participants received lung-sparing surgeries and another treatment called photodynamic therapy that uses light to kill cancer cells. Ninety-two percent of the group also received chemotherapy.

The study volunteers achieved far longer survival times, said study author Dr. Joseph Friedberg.

“When you take the [entire] lung out, it’s a significant compromise in quality of life,” said Friedberg. He’s director of the University of Maryland Medical Center’s Mesothelioma and Thoracic Oncology Treatment and Research Center in Baltimore.

“For all intents and purposes, this [lung-sparing surgical approach] is the largest palliative operation known to man, since chances of curing mesothelioma are vanishingly small,” said Friedberg. He completed the research while at his previous post at the University of Pennsylvania.

“Plus, most of these patients are elderly, so preserving quality of life was really the goal,” he added.

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Source: Lung-sparing surgery may boost mesothelioma survival


 

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Asbestos-related cancer won’t be overcome anytime soon, doctors say

New methods are giving doctors a better handle on diagnosing and treating asbestos-related cancers, but no cures are on the horizon.

“I think it would be overly optimistic to say it’s going to be cured. I mean we can always dream,” said oncologist Dr. Christopher Lee, an expert on mesothelioma.

Paul Demers, a senior scientist in prevention at the Occupational Cancer Research Centre in Toronto, said one of the difficulties in diagnosing mesothelioma is the long latency period — the period between exposure and the development of symptoms — which can sometimes be up to 40 years.

When asbestos fibres are inhaled or ingested, they become trapped in the pleural lining of the lungs. Over time, thousands of tiny fibres cause scarring in the tissue.

New equipment like the CyTOF instrument allows doctors to detect asbestos earlier and with more precision, which could facilitate more effective treatments for asbestos victims.

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Source: Asbestos-related cancer won’t be overcome anytime soon, doctors say


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Malignant Mesothelioma in a Motor Vehicle Mechanic

Case reports remain an important source of data in the debate over the carcinogenic effect of asbestos-containing automotive friction products. This report documents a case of pleural mesothelioma accompanied by asbestos bodies in the lung tissue of a career auto mechanic with no other known sources of exposure. Previously unreported historical and contemporary exposure data are also discussed in the context of providing additional support for the proposition that work with asbestos-containing automotive products presents a risk of significant exposure. While there remains a body of negative epidemiology that fails to find an increased risk of disease among auto workers, those data must be approached with caution. Many of those studies have drawn technical criticisms, which are beyond the scope of this report, but they remain a key part of the legal defense mounted by defendant-companies who are involved in asbestos-related litigation. This ongoing debate provides the context for the continued relevance of case reports such as this one, as well as the presentation of new and previously unpublished exposure data.

Source: Malignant Mesothelioma in a Motor Vehicle Mechanic


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Deadly Remnants of Asbestos in Italy (photos slideshow)

Although Italy joined asbestos-producing nations in banning the carcinogenic material at the end of the 20th century, thousands of people working in factories and living in public housing had already been exposed. In other words, as the Italian photographer Cinzia Canneri explained, the damage had been done by the 1980s.

Ms. Canneri said it could take up to 30 years after exposure for diseases like asbestosis or mesothelioma to develop. As a result, large numbers of people in the last decade have begun to suffer in Italy and more are expected to — with few legal or medical protections.

“They have not been recognized as victims,” Ms. Canneri said through an interpreter. “They want to speak and be heard.

”To help them, Ms. Canneri spent the last two years closely following asbestos victims, documenting their daily lives and struggles as they deal with new diseases, mourn deceased family members, visit doctors and contemplate whether or not time is running out on their health.

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Source: Deadly Remnants of Asbestos in Italy (photos slideshow)


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Asbestos ban to be announced by federal government next week

The federal government plans to announce a comprehensive ban on asbestos in Canada next week, CBC News has learned.

The country currently allows imports of construction products and automotive parts that contain the toxic fibre, even though Canada no longer exports the material.

Asbestos is known to cause deadly cancers and lung diseases, and has already been banned in Europe, Australia and Japan. The World Health Organization recommends replacing asbestos with safer substitutes.

Canadian labour and public health groups have been calling for a comprehensive ban for years.

About 2,000 Canadians die of asbestos-related diseases every year — many of those deaths have been linked to asbestos exposure in the workplace.

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Source: Asbestos ban to be announced by federal government next week


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Canada should stop importing deadly asbestos, labour group says

The Canadian Labour Congress is calling for a ban on asbestos.

Exposure to asbestos — a fibrous mineral used in building and construction — is the leading cause of workplace-related death in Canada.

Canada stopped exporting asbestos in 2011, and its last asbestos mine closed in 2012. But Canada still imports asbestos for use in construction products and automotive parts.

According to the Canadian Labour Congress, the value of the imports has increased from $4.7 million in 2011 to $8.2 million in 2015.

Hassan Yussuff, president of the Canadian Labour Congress, told CBC’s The Early Edition the government needs to step up and ban the import of asbestos.

“We only stopped exporting it because the mine went bankrupt, not because this is good public policy.  We knew the evidence long before that asbestos is a carcinogen.”

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Source: Canada should stop importing deadly asbestos, labour group says


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