Identification Of Gene Alterations in Asbestos-Related Cancers Like Non-Small Cell Lung Cancer Shows A Synergistic Effect Of Asbestos And Tobacco Smoke

An article published by the medical journal Mutagenesis in February 2013, “Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma” shows the synergistic effect between asbestos exposure and cigarette smoking.

As background,  lung cancer has been shown to be caused by both tobacco smoke and asbestos exposure, as well as other carcinogens. Exposure to both tobacco smoke and asbestos greatly enhances that risk so that the total risk is greater than adding the individual effects (a toxicology effect called synergism). If asbestos exposure increases your chance of getting cancer by 5 times and smoking increases your chance of getting cancer by 12 times, then being exposed to both of them can increase your chances by 60 to 100 times.

From the Absract for this February 2013 Mutagenesis article, which was based on a French study:

Given the interest in defining biomarkers of asbestos exposure and to provide insights into asbestos-related and cell-specific mechanisms of neoplasia, the identification of gene alterations in asbestos-related cancers can help to a better understanding of exposure risk. To understand the aetiology of asbestos-induced malignancies and to increase our knowledge of mesothelial carcinogenesis, we compared genetic alterations in relevant cancer genes between lung cancer, induced by asbestos and tobacco smoke, and malignant pleural mesothelioma (MPM), a cancer related to asbestos, but not to tobacco smoke…. While genetic changes in [non-small cell lung cancer (NSCLC)] are dominated by the effects of tobacco smoke, the increase of transversions in TP53 gene is consistent with a synergistic effect of asbestos. These results may help to define cell-dependent mechanisms of action of asbestos and identify susceptibility factors to asbestos.

Lastly, we want you to know that there is evidence that quitting smoking will reduce the risk of lung cancer among people who have been exposed to asbestos dust, perhaps by as much as half after at least 5 years without smoking tobacco.


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

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Increased Risk Of Pleural Mesothelioma Where There Was Asbestos Exposure Together With Mineral Wool And/Or Silica Exposure, Also (i.e., Co-exposure)

The medical journal American Journal of Respiratory and Critical Care Medicine published this article early online on March 7, 2013:   “Pleural Mesothelioma and Occupational Co-exposure to Asbestos, Mineral Wool and Silica”.

From the Abstract for this new medical journal article about mesothelioma:

Rationale: Occupational co-exposure to asbestos and other fibers or particles could modify the carcinogenicity of asbestos with regard to pleural mesothelioma.

Objectives: To estimate associations between pleural mesothelioma and occupational mineral wool [(MW)] and silica exposure and to study the impact of occupational co-exposure on the risk of pleural mesothelioma….

Conclusion: Our results are in favour of an increased risk of pleural mesothelioma for subjects exposed to both asbestos and [mineral wool (MW)] or asbestos and silica.

This March 2013 article was based on a French pooled case-control study.

We will continue to monitor the literature for medical developments concerning mesothelioma (“meso”).


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

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Amateur Do-It-Yourself (DIY) Home Renovators Exposed To Asbestos Can Develop Mesothelioma, Asbestos Lung Cancer, Or Asbestosis

This March 7, 2013 newspaper article, “Renovators the ‘third wave’ of asbestos victims”, was published in Australia, but the points it makes are valid here in the United States and elsewhere around the world. To get your attention, perhaps, the sub-headline for this article refers to asbestos as the “silent killer”.

The first wave of victims were those exposed as part of the asbestos mining industry, the second wave was the tradesmen who worked with asbestos products in buildings.

“The third wave is home renovators,” Mr Slevin said.

“That’s people pulling up carpet and the underlay, people pulling out bathrooms, doing some of their own under-house work and being exposed.”

It is these people who are adding to the numbers of people being diagnosed with asbestos-related cancer….

“Despite a general sense that the problem’s been fixed after asbestos was banned around 1983.

“Asbestos was a very good building product, it was cheap and had a number of very useful purposes.

“It’s very common in property built, particularly in Western Australia at least, from the mid 1940s to the early 1980s so that means there’s still a lot of asbestos in those properties, domestic and public.”

Home renovators

It’s estimated that two out of three homes built in Australia between World War 2 and the early 1980s still contain asbestos and it’s those houses that are now being renovated or modified to suit new owners.

There is also a new generation of home renovators and tradespeople who were born after asbestos was banned and may not easily recognise the deadly product for what it is….

“So, the bottom line is it’s still around, it’s gone off the radar, people are still being exposed to it and the number of cases of asbestos-related diseases is still going up.

If you or someone you know does DIY home renovations or repairs, be mindful of older products which may contain asbestos during your work.

As this article points out, asbestos is not called the “silent killer” for nothing.


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

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News Report Of Two Mesothelioma Deaths Show Similarities And Differences In These Types Of Asbestos Cases

An October 30, 2012 article, “Two more die from “dreadful” mesothelioma”, published by a newspaper in the United Kingdom (UK) serves to show how asbestos-mesothelioma cases can be very similar yet very different in their sets of relevant facts.

Keith Ison, 62, was diagnosed with mesothelioma in March 2012 and died on July 6, just three months after his diagnosis.  An autopsy found a tumor encasing his right lung and tiny fibers of asbestos were found in the lung.  Mr. Ison had told doctors he was exposed to asbestos when working as a builder for a company between 1971 and 1973.

Dennis Grimsey, 81, was diagnosed with mesothelioma in April 2012 and died about three months, on July 8.  An autopsy revealed his left lung was encased in a tumor and asbestos fibers were found in the lung.  However, in this instance, Mr. Grimsey had not been aware he had been exposed to asbestos, although he said he had worked briefly in the construction industry many years earlier.

The similarities for these two asbestos-mesothelioma death cases are:

  • relative brief period of asbestos exposure;
  • the asbestos exposure was many years before the mesothelioma diagnosis; and,
  • death within a few months after the mesothelioma was diagnosed.

The differences are:

  • the age at death: 62 years old vs. 81 years old; and,
  • one individual recalled working with or around asbestos-containing products, while the other was unaware of when or where he had been exposed to asbestos.

Even though these mesothelioma case reports come out of the UK, they are instructive as to how asbestos causes mesothelioma in people many years after their asbestos exposure, whether they knew how they were exposed to asbestos or not.


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

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An Asbestos-Mesothelioma Death In The UK That Hits Home With Anyone Who Has Lost A Loved One To An Asbestos Disease

The title of this news article from the United Kingdom (UK) speaks to all who have been affected by asbestos and mesothelioma, regardless of where one lives:

 ’He just hoped he would be one of the lucky ones.  We were all devastated that he wasn’t’.

In this instance, it was Michael Wareham (on the left in picture below) who died in 2010 of mesothelioma, an asbestos-related cancer, at age 73.

Michael Wareham, left, who died in 2010 of an asbestos-related cancer, aged 73.

 

From that UK news article:

He claimed he was regularly exposed to the dust when he worked at the Watford Timber Co Ltd in the 1950s and 1960s as a joiner and machinist, cutting asbestos sheets. Years later, when he learned of the dangers of the material, he told his family he hoped he would be one of the lucky ones, but unfortunately they were left heartbroken.

Someone like Michael Wareham or his family here in the U.S. may be entitled to legal compensation from an asbestos lawsuit or a workers compensation claim filed by an asbestos attorney because asbestos exposure causes mesothelioma, asbestos cancers like lung cancer, and asbestosis.

While I handle these asbestos cases I surely wish that my services were not needed and that no one went through what Michael Wareham and his family did.

Homing in on rising toll of asbestos

Quoted from http://au.news.yahoo.com/thewest/lifestyle/a/-/health/14840033/homing-in-on-rising-toll-of-asbestos/

Homing in on rising toll of asbestos

Alison Batcheler, The West Australian Updated September 13, 2012


The Office of Asbestos Safety, announced by the Federal Government last week, will develop a plan to remove asbestos from government and commercial buildings by 2030 and label asbestos in homes to alert tradesmen, tenants and buyers.

 

MESOTHELIOMA EXPLAINED: This incurable cancer occurs in the pleural tissue layers that coat the inside of the chest wall and the outside of the lung and is almost always caused by asbestos exposure, according to Edward Fysh, Sir Charles Gairdner Hospital respiratory physician and Lung Institute of WA researcher.

Once inhaled, the long, pointy, sharp asbestos crystals spear through the airway walls and deposit in the pleural space, where they cause ongoing, low-grade inflammation. The immune system often fails to clear these fibres.

 

These fibres over time, often 20-40 years after inhalation, lead to the development of mesothelioma. While not all people exposed to asbestos will develop mesothelioma, a small exposure can be enough to trigger the cancer.

[Article continues at original source]

Victim links mesothelioma to asbestos at school

Quoted from http://www.abc.net.au/news/2012-09-05/mcdonald-suspects-asbestos-cause-of-mesothelioma/4243764

Victim links mesothelioma to asbestos at school

Updated 10 hours 11 minutes ago

asbestos removal sign

Photo: The use of asbestos was widespread decades ago and its removal requires experts. (Stateline) Map: Wagin 6315

A 49-year-old man says he may have contracted mesothelioma as a child while attending a high school in country Western Australia.

John McDonald was diagnosed with the asbestos-related cancer last year.

He is appealing for information from people who were students or teachers at Wagin Junior High in the early 1970s when James Hardie products are believed to have been used for an extension.

[Article continues at original source]

Deadly Legacy: Asbestos’ third wave of victims

Quoted from http://blogs.abc.net.au/wa/2012/09/deadly-legacy-asbestos-third-wave-of-victims.html

Deadly Legacy: Asbestos’ third wave of victims

04/09/2012 , 5:05 PM by Emma Wynne

Philip and ross

Philip Noble (left) and Ross Munroe (right) as toddlers playing in an asbestos pit in Wittenoom. Image Supplied: Wittenoom Asbestos Mining Company.

The Noble family moved to Wittenoom in 1954 – 4 out of the 5 in that family are now dead from Asbestos disease. Survivor Derryn Carnaby, who has lost both her parents and two brothers, is now an advocate for the Asbestos Disease Society of Australia. Derryn Carnaby spoke to John McGlue on Mornings.

Hear the full interview here:

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Evaluation of take home (para-occupational) exposure to asbestos and disease: a review of the literature.

Quoted from http://highwire.stanford.edu/cgi/medline/pmid;22913651

Evaluation of take home (para-occupational) exposure to asbestos and disease: a review of the literature.
.

   
   
 
 
 

EP Donovan, BL Donovan, MA McKinley, DM Cowan, and DJ Paustenbach
Crit Rev Toxicol, August 22, 2012;

 
 
 
 
 
 

The potential for para-occupational (or “take-home”) exposure to a number of chemicals has been recognized for over 60 years. We conducted a literature review in order to characterize reported cases of asbestos-related disease among household contacts of workers occupationally exposed to asbestos. Over 200 published articles were evaluated. Nearly 60 articles described cases of asbestos-related disease thought to be caused by para-occupational exposure. Over 65% of these cases were in persons who lived with workers classified as miners, shipyard workers, insulators, or others involved in the manufacturing of asbestos-containing products, with nearly all remaining workers identified as craftsmen. 98% of the available lung samples of the persons with diseases indicated the presence of amphibole asbestos. Eight studies provided airborne asbestos concentrations during (i) handling of clothing contaminated with asbestos during insulation work or simulated use of friction products; (ii) ambient conditions in the homes of asbestos miners; and (iii) wearing previously contaminated clothing. This review indicates that the literature is dominated by case reports, the majority of which involved household contacts of workers in industries characterized, generally, by high exposures to amphiboles or mixed mineral types. The available data do not implicate chrysotile as a significant cause of disease for household contacts. Also, our analysis indicates that there is insufficient information in the published literature that would allow one to relate airborne asbestos concentrations in a workplace to those that would be generated from subsequent handling of contact with clothing that had been contaminated in that environment. Ideally, a simulation study could be conducted in the future to better understand the relationships between the airborne concentrations in the workplace and the fiber characteristics that influence retention on fabric, as well as the concentrations that can be generated by handling the contaminated clothing by the persons in the home.

How a few minutes of DIY can cost your life years later: Hidden asbestos in homes putting millions at risk from deadly lung disease

Quoted from http://www.dailymail.co.uk/health/article-2194460/How-minutes-DIY-cost-life-years-later-Hidden-asbestos-homes-putting-millions-risk-deadly-lung-disease.html

How a few minutes of DIY can end up costing you your life: Hidden asbestos in homes putting millions at risk from deadly lung disease

By Anna Hodgekiss

PUBLISHED: 20:43 EST, 27 August 2012 | UPDATED: 05:04 EST, 28 August 2012

Dr Geoffrey Newton, aged 81, died from mesothelioma

Dr Geoffrey Newton, aged 81, died from mesothelioma

Geoffrey Newton had always prided himself on his DIY skills.

Even aged 81, he was fitting a new kitchen and bathroom in his home.

‘Over the years he’d done everything from building a boat to converting an old school house into our home,’ says his wife Pat, 82, a former GP.

‘He was brilliant at DIY. Nothing was ever too much of a challenge.’

Unfortunately, it was this passion that most likely led to Mr Newton’s death in May.

He was suffering from mesothelioma — cancer of the lining of the lungs — caused by exposure to asbestos.

Experts say that even a few hours’ exposure to the toxic fibres can be enough to trigger the condition later in life.

And a few hours was all it had taken for Mr Newton, a leading orthopaedic surgeon, to remove an old central heating boiler packed with white asbestos from his house in Burton-on-Trent.

‘It was 37 years ago, but I still remember all the white dust that came out with it,’ says Pat.

‘At the time, it was known that brown and blue asbestos (there are three types) were dangerous, but not white, so we assumed the dust was harmless.

‘But it’s the only occasion we can think of that Geoffrey was exposed to it, so that must have been the trigger.’

While asbestos has left a cruel legacy for families such as the Newtons, experts are warning it is still very much a risk, mainly due to thousands of homeowners who could unwittingly disturb asbestos while embarking on home renovations.

[Article continues at original source]

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