Pleural malignant mesothelioma in dental laboratory technicians: A case series

Asbestos was used in dentistry as a binder in periodontal dressings and as lining material for casting rings and crucible. However, until now, only one case of malignant mesothelioma with occupational exposure to asbestos in dental practice has been reported. We present 4 pleural mesotheliomas out of 5344 cases identified in Lombardy, Italy, in 2000-2014. Three men had been working as dental laboratory technicians, with asbestos exposure for 10, 34, and 4 years, and one woman had been helping her husband for 30 years in manufacturing dental prostheses. The men described the use of asbestos as a lining material for casting rings, while the woman was not able to confirm this use. We confirm the association of malignant mesothelioma with dental technician work. Dental technicians suffering from mesothelioma should be questioned about past occupational asbestos exposure.

[Read article in full at original source]

Source: Pleural malignant mesothelioma in dental laboratory technicians: A case series


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Asbestos Deaths Remain A Public Health Problem

People are still dying of cancer linked to asbestos, the U.S. Centers for Disease Control says, despite decades of regulations meant to limit dangerous exposure.

Starting in 1971, the Occupational Safety and Health Administration has regulated how much asbestos workers can be exposed to, because it contains tiny fibers that can cause lung disease or cancer if they are swallowed or inhaled.

The Environmental Protection Agency regulates asbestos too, setting requirements for inspecting, demolishing and renovating buildings that contain materials made with asbestos, like insulation, vinyl tiles, roofing, shingles and paint.

But, a recent CDC analysis found that thousands of people are still dying each year from a type of cancer called malignant mesothelioma that is associated with inhaling asbestos fibers, even briefly or in small amounts. Even after decades of regulation, between 1999 and 2015 there were 45,221 mesothelioma deaths in the U.S. The majority of those who died were men.

The greatest increase is among people over 85 years old, who were likely exposed to asbestos many years ago. It can take anywhere from two to seven decades for mesothelioma to develop after a person inhales asbestos fibers. And early deaths among people 35 to 65 are down overall.

[Read article in full at original source]

Source: Asbestos Deaths Remain A Public Health Problem


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model

Background  Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed. Immunosuppressant FTY720, approved for multiple sclerosis treatment, has recently raised attention for its anti-tumor activity in a variety of cancers. However, its therapeutic potential in MM has not been evaluated yet.

Methods  Cell viability and anchorage–independent growth were evaluated in a panel of MM cell lines and human mesothelial cells (HM) upon FTY720 treatment to assess in vitro anti-tumor efficacy. The mechanism of action of FTY720 in MM was assessed by measuring the activity of phosphatase protein 2A (PP2A)—a major target of FTY720….

Conclusions  Our preclinical data indicate that FTY720 is a potentially promising therapeutic agent for MM treatment.

[Read article in full at original source]

Source: FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Malignant mesothelioma due to asbestos exposure in dental tape

Although most cases of malignant mesothelioma of the pleura are caused by one or more readily recognized sources of exposure to asbestos, cases of the disease with more occult exposure occur, especially since asbestos has been used in over 3,000 products. Dental lining tape contained asbestos from the 1930s until at least the 1970s and was used in the lost wax method of casting crowns, bridges, and other metal dental prosthetic devices. We report six cases of pathology-verified malignant mesothelioma, mostly among dentists, following exposure to airborne dust from asbestos dental tape, which resulted in asbestos tort litigation. According to evidence available at present, chrysotile asbestos was the type of asbestos used in dental tape in the past in the United States, and the described cases followed relatively brief and intermittent exposure to this type of asbestos. These cases underscore the need for comprehensive exposure histories to determine exposure scenarios.

[Read article in full at original source]

Source: Malignant mesothelioma due to asbestos exposure in dental tape


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Clinical Safety and Activity of Pembrolizumab in Patients With Malignant Pleural Mesothelioma

BACKGROUND  Malignant pleural mesothelioma is a highly aggressive cancer with poor prognosis and few treatment options following progression on platinum-containing chemotherapy. We assessed the safety and efficacy of pembrolizumab (an anti-programmed cell death receptor 1 [PD-1] antibody) in advanced solid tumours expressing programmed cell death ligand 1 (PD-L1) and report here on the interim analysis of the malignant pleural mesothelioma cohort.

METHODS  Previously treated patients with PD-L1-positive malignant pleural mesothelioma were enrolled from 13 centres in six countries. Patients received pembrolizumab (10 mg/kg every 2 weeks) for up to 2 years or until confirmed progression or unacceptable toxicity….

FINDINGS  As of June 20, 2016, 25 patients received pembrolizumab. 16 (64%) patients reported a treatment-related adverse event; the most common adverse event were fatigue (six [24%]), nausea (six [24%]), and arthralgia (five [20%])….

INTERPRETATION  Pembrolizumab appears to be well tolerated and might confer anti-tumour activity in patients with PD-L1-positive malignant pleural mesothelioma. Response durability and efficacy in this patient population warrants further investigation.

[Read full article at original source]

Source: Clinical Safety and Activity of Pembrolizumab in Patients With Malignant Pleural Mesothelioma


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

EPA Asbestos Review May Trigger Probe of Chlorine Industry

Chlorine manufacturers, which currently are the largest U.S. importers of asbestos, could have their use of the mineral reviewed soon if the Environmental Protection Agency selects asbestos as one of the first 10 substances it will analyze under the amended chemicals law.

Chlorine and caustic soda are manufactured by the chlor-alkali industry, which uses asbestos for one of three processes that companies can use to produce both chemicals. The U.S. Geological Survey has listed the chlor-alkali industry as the primary importer of asbestos in each annual mineral commodity summary the service has published since 2013. The industry’s use accounted for 90 percent of the 358 tons of asbestos imported into the country in 2015, the geologic survey said in its 2016 summary.

The chlor-alkali industry’s use of asbestos should be evaluated by the EPA as part of an assessment of the risks posed by the mineral, Linda Reinstein, president of the nonprofit advocacy group Asbestos Disease Awareness Organization (ADAO), told Bloomberg BNA Sept. 9 [2016].

[Article continues at original source]

Source: EPA Asbestos Review May Trigger Probe of Chlorine Industry


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Asbestos exposure is still making people sick

Researchers at the US Centers for Disease Control and Prevention are struggling to understand why younger populations continue to suffer asbestos-related medical issues despite efforts to reduce exposure from the toxic mineral.

According to a report released by the CDC on Thursday, numbers of deaths related to malignant mesothelioma increased from 2,479 in 1999 to 2,597 in 2015.

The largest increase was seen in those over 85 years old, but younger populations continue to be affected.

In those 16 years, 16,914 of the deaths were among people 75 to 84 years old. In the same period, 682 people between the ages of 25 and 44 died of mesothelioma-related problems.

“Although deaths among persons aged less than 35 years are of concern, we do not have information to understand potential causes,” said Dr. Jacek Mazurek, lead author of the CDC report.

Source: Asbestos exposure is still making people sick


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Mesothelioma deaths alert US to continuing asbestos exposure

A paper from the National Institute for Occupational Safety and Health (Niosh) reveals that the latest data for deaths linked to mesothelioma show increases between 1999 and 2009. The trend was for both sexes and all ethnic groups, and the authors remark that the “continuing deaths of those aged less than 55 suggests continuing exposure to asbestos fibres”.

Continuing deaths from malignant mesothelioma, the lung disease associated with asbestos fibres, have alerted the US health authorities of the need for continuing efforts to prevent exposure…..

The US Geological Survey produced a commodity summary in January 2016, which says that the chloralkali industry accounted for 90% of US consumption of 360 tons in 2015. Its use by the industry is for diaphragms which separate anode and cathode products in chloralkali electrolytic cells. The remainder is used in coatings and compounds, plastics and roofing products.
[Read full article at original source]

Source: Mesothelioma deaths alert US to continuing asbestos exposure


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Asbestos Case Beats Statute of Limitations

A federal judge has denied a pump manufacturer’s argument that an asbestos-related lung cancer case should be tossed because it wasn’t filed in time.

As asbestos litigation continues its steady decline and fewer lawsuits against companies for asbestos-related illnesses make it past the early stages of litigation, plaintiff Kathleen Conneen’s case on behalf of her deceased husband, Joseph Conneen, has cleared a significant hurdle.

U.S. District Judge Eduardo C. Robreno of the Eastern District of Pennsylvania denied defendant Goulds Pumps Inc.’s motion for summary judgment based on Pennsylvania’s two-year statute of limitations in asbestos cases, and under maritime law. Joseph Conneen worked in a shipyard.

The primary dispute centers on when Kathleen Conneen’s husband learned his exposure to asbestos could have been a factor in his diagnosis. According to Robreno’s opinion, Joseph Conneen, who filed suit in January 2015, was diagnosed with lung cancer in December of 2012.

Kathleen Conneen argued that her husband did not learn that asbestos exposure was a possible factor until February 2013, while Goulds countered that since Conneen’s husband worked around asbestos for 28 years and never smoked, he should have been more diligent in trying to identify the cause of his cancer.

[Article continues at original source]

Source: Asbestos Case Beats Statute of Limitations

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Arizona High Court to Rule on Liability in Asbestos Take Home Exposure Case

The Arizona Supreme Court has agreed to consider whether employers can be held liable to somebody who contracted cancer from asbestos brought home on a parent’s work clothes.

The case stems from the 2014 death of Dr. Ernest Quiroz, whose 2013 negligence lawsuit contends he was exposed to asbestos on his father’s work clothes.

The facts as outlined in the appeal indicate he lived with his father from 1952 to 1966, during the time his father worked at Reynolds Metal Co. Dr. Quiroz lived in California until 1976 and in Michigan until his death in 2014. The suit alleges Dr. Quiroz contracted mesothelioma as a result of the exposure to his father’s work clothes.

The suit argues that Reynolds Metal Co. was legally obligated to avoid creating hazardous conditions that would injure people off its property.

Reynolds won a pretrial ruling by a trial judge, and the Court of Appeals upheld it.

The Court of Appeals said potential drawbacks of recognizing what’s called a duty of care in so-called “take-home exposure” cases outweigh potential benefits, partly by opening the door to liability claims involving an array of hazardous materials.

Source: Arizona High Court to Rule on Liability in Asbestos Take Home Exposure Case

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, NC 28403
Tel: (800) 426-9535
Email@LambLawOffice.com
Disclaimer and Copyright