Radiotherapy to intervention sites in mesothelioma: no more?

Malignant pleural mesothelioma is a tumour with a dismal prognosis, and its incidence is increasing worldwide as a result of widespread exposure to asbestos. Because of the pattern of tumour growth, the ipsilateral chest wall is often involved. Moreover, histological diagnosis is usually obtained by pleural biopsy, via video-assisted thoracoscopic surgery or other invasive procedures, which can result in tumour seeding at the site of the intervention. Chest wall involvement, including procedure-tract metastases, can lead to severe symptoms, mostly pain. Accordingly, local control in malignant pleural mesothelioma is a major challenge.

Radiotherapy has been widely used in the past decades in the treatment of patients with malignant pleural mesothelioma, as a part of a multimodality therapy for early-stage disease,1, 2 in the palliation of pain,3 and in the prophylaxis of track-site recurrence….

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Source: Radiotherapy to intervention sites in mesothelioma: no more? – The Lancet Oncology

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