Published Online: Monday, October 5, 2015
Mark A. Socinski, MD: So in keeping with the same theme, we saw another antibody that’s been a part of our practice, bevacizumab, for years in nonsquamous non-small cell lung cancer, a very interesting trial from the French, the Mesothelioma trial, in which there was a clear survival advantage. Mary Jo, do you want to walk us through that?
Mary Jo Fidler, MD: It was a randomized trial of standard chemotherapy for mesothelioma with cisplatin and pemetrexed and the randomization was to add bevacizumab. And the study met its survival endpoint with a median survival reaching over the one year mark. I consider it a positive trial and I would use bevacizumab in this setting. I find it interesting for a couple of reasons. One is its movement in the disease that hasn’t had a lot of progress in several years.
Mark A. Socinski, MD: Well, much like squamous, right?
Roy S. Herbst, MD, PhD: Yes.
Mary Jo Fidler, MD: And a second thing, most of the non-small cell lung cancer data with bevacizumab, if it’s helping, it seems to be helping when you add it to a taxane backbone. Maybe there’s some antigenic synergism with the taxanes, but the data not including the taxane has been less impressive with pemetrexed in the European AVAIL trial. So bevacizumab reached its endpoint and it may be that the angiogenic pathway is much more important in mesothelioma.
Mark A. Socinski, MD: Is this an advance, Naiyer, in your opinion?
Naiyer Rizvi, MD: Absolutely! Mesothelioma is such a tough disease to treat, and I think that having a phase III trial that met its survival endpoint is very real and I think it changes practice.
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