From a summer 2013 edition of Case Reports in Oncological Medicine we get an interesting article about two patients diagnosed with pericardial malignant mesothelioma.
The first case involved a 57-year old man with a two-month history of dyspnea on exertion and dizziness and three days of rapidly progressive dyspnea. His past medical history was unremarkable.
The second case a 27-year-old man presented with chest pain and was treated as tuberculous pericarditis because he presented with constrictive pericarditis with lymphocytic pericardial effusion. His past medical history was unremarkable, also.
From this recent medical journal article, “Malignant Mesothelioma of the Pericardium: A Report of Two Different Presentations”:
Malignant mesothelioma of the pericardium is a rare and fatal condition that clinicians should be aware of due to its variability of clinical manifestation. The diagnosis may be delayed as a result of delayed treatment. Here, we report two cases of malignant pericardial mesothelioma with two different clinical aspects: cardiac tamponade and mimic tuberculous pericarditis. Both patients: may have indirect exposure to asbestos. Despite chemotherapy, both patients died at 2 weeks and 3 months after the diagnosis. Malignant mesothelioma of the pericardium is fatal, has a variety of presentation, and may not be related to asbestosis exposure.
Malignant pericardial mesothelioma is extremely rare and has poor prognosis. It accounted for only 0.3% of mesothelioma death worldwide. Unlike pleural mesothelioma, the relationship between asbestos and this lethal tumor is unclear. Patients usually present with dyspnea on exertion caused by pericardial effusion or heart failure. The characters of pericardial effusion, however, may be different such as cardiac tamponade or constrictive pericarditis. Here, we reported two patients diagnosed as pericardial malignant mesothelioma with two different presentations….
Malignant mesothelioma of the pericardium is fatal, has a variety of presentation, and may not be related to asbestosis exposure. CT scan of enhanced soft tissue nodules infiltrating the pericardium may be a clue for diagnosis.
This medical article also points out that “no standard treatment guideline for pericardial mesothelioma has been established yet.”
We will continue to monitor the medical journals for reports about developments concerning the treatment of malignant mesothelioma, be it for the pleural, peritoneal, or pericardial type of “meso” (as it is sometimes called).
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