How Is Localized Malignant Pleural Mesothelioma Different From The More Common Diffuse Form Of Mesothelioma

According to the World Health Organization (WHO), localized malignant mesothelioma of the pleura (LMM) is histologically identical to diffuse malignant mesothelioma but without any evidence of pleural spread, i.e., localized.

There is an impression that localized malignant mesothelioma of the pleura (LMM) may have a better outcome than the more common diffuse form of mesothelioma. Treatments for LLM include different combinations of surgery, chemotherapy, and radiotherapy.

This issue was explored in this November 2012 medical journal article, “What is the survival after surgery for localized malignant pleural mesothelioma?”. From the Abstract:

In order to advise our patients on prognosis, we studied the duration of survival after surgical resection of [localized malignant mesothelioma of the pleura (LMM)]. A total of 150 papers were found, of which 16 represented the best evidence to answer the question…. Some report median survival (range: 11.6–36 months) and others disease-free survival (range: 0 months to 11 years). Median survival to the longest follow-up was 29 months when calculated by pooling data from informative papers using the Kaplan–Meier method. Our review suggests that survival in [localized malignant mesothelioma of the pleura (LMM)] is longer than that generally quoted for the more common diffuse form of malignant mesothelioma. Hence, aggressive treatment of LMM may be reasonable in appropriate patients.

We will continue to monitor the medical journals for reports concerning mesothelioma treatments and survival times.

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