Malignant Pleural Mesothelioma: Localized vs. Diffuse Disease: Range Of Survival Times After Surgical Treatment

In January 2013 the Interactive CardioVascular and Thoracic Surgery (ICVTS) medical journal published this article, “What is the survival after surgery for localized malignant pleural mesothelioma?” (Full text: Free).

Here are some basic facts taken from the Abstract for this new 2013 medical article about localized malignant mesothelioma of the pleura as regards survival after treatment:

  • Treatments for [localized malignant mesothelioma of the pleura (LMM)] include different combinations of surgery, chemotherapy and radiotherapy. There is an impression that LMM may have a better outcome than the commoner diffuse form of malignant mesothelioma that has been reported to have a survival between 8 and 14 months.
  • It is difficult to combine the results of these 16 papers because both treatments and results are reported differently. Some report median survival (range: 11.6–36 months) and others disease-free survival (range: 0 months to 11 years). Median survival to the longest follow-up was 29 months when calculated by pooling data from informative papers using the Kaplan–Meier method.
  • Our review suggests that survival in LMM is longer than that generally quoted for the more common diffuse form of malignant mesothelioma. Hence, aggressive treatment of LMM may be reasonable in appropriate patients.

In our next Asbestos HUB article we will look at how the Division of Thoracic Surgery in the Department of Cardiothoracic Surgery at the Stanford School of Medicine approaches malignant pleural mesothelioma cases.

 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

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