Prognosis and prognostic factors of patients with mesothelioma: a population-based study.

Quoted from http://highwire.stanford.edu/cgi/medline/pmid;22644294

Prognosis and prognostic factors of patients with mesothelioma: a population-based study.

S van der Bij, H Koffijberg, JA Burgers, P Baas, MJ van de Vijver, BA de Mol, and KG Moons
Br J Cancer, May 29, 2012; .

 
 
 

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, P.O. Box 85500, GA Utrecht 3508, The Netherlands.

 


Background
: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management.Methods:We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008.

 
Results: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26-2.22)).

Conclusion: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis.

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