Current Systemic Management of Pleural Malignant Mesothelioma

Abstract

Malignant mesothelioma remains an uncommon malignancy of the pleura. Standard systemic therapy involves the use of pemetrexed and cisplatin. Recent results of a phase III, randomized clinical trial presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in June 2015 support the addition of bevacizumab to this regimen. The study showed that the addition of bevacizumab improved progression-free survival and overall survival in those without contraindications to vascular endothelial growth factor inhibitor therapy. Second-line therapies yield modest efficacy, but commonly used agents include vinorelbine and gemcitabine, largely based on small phase II trials prior to the first-line use of pemetrexed. Efforts are ongoing to improve systemic options in all lines of therapy. Based on the success in other disease, promising new drugs are being explored that target key aberrant pathways in mesothelioma. Additionally, the advent of immunotherapies has led to some exciting results in mesothelioma….

 

Plaintiffs Reload in Fraud Case Against Cahill, BASF

After winning a high-profile appellate reversal last year, plaintiffs lawyers at Cohen, Placitella & Roth and Fox Rothschild have filed revamped allegations that Cahill Gordon & Reindel and BASF Catalysts conspired to destroy evidence in sprawling asbestos litigation….

The filing marks the latest development in a proposed class action brought in 2011 by the relatives of people who allegedly died from exposure to asbestos-contaminated talc made by Engelhard Corp., which BASF acquired in 2006. As The American Lawyer detailed in a feature story last year, Cahill and BASF are accused of conspiring to destroy and conceal evidence relevant to separate litigation brought by alleged asbestos victims.

The plaintiffs’ fraud allegations against Cahill and BASF are sweeping, tracing back more than 25 years to a 1979 lawsuit over the death of a former Engelhard employee. After BASF, through lawyers at Cahill, settled that lawsuit in 1984, the plaintiffs allege that BASF began directing employees to discard documents that related to asbestos in the company’s talc.

[Article continues at original source]

Source: Plaintiffs Reload in Fraud Case Against Cahill, BASF


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Immune Checkpoint Blockade in Malignant Mesothelioma

Malignant mesothelioma (MM) is a highly aggressive malignancy with a very dismal prognosis. Current treatment for unresectable MM is largely unsatisfactory; therefore, new therapeutic approaches are eagerly awaited. A better understanding of the complex mechanisms of immune escape operated by neoplastic cells and the ability to unleash an efficient anti-tumor immune response by targeting regulatory immune checkpoint(s) with immunomodulatory monoclonal antibodies (mAbs), is leading to very promising clinical results in different tumor types. Herein, we highlight the clinical impact so far identified for these new immunomodulatory agents in MM patients and discuss their prospective use to design novel clinical trials.

[Article continues at original source]

Source: Immune Checkpoint Blockade in Malignant Mesothelioma – Seminars in Oncology


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

 

Katko Introduces Bipartisan Legislation to Create National Mesothelioma Patient Registry

 Congressman John Katko

July 29, 2015 Press Release

WASHINGTON, D.C. – U.S. Representative John Katko (NY-24) today introduced bipartisan legislation in the U.S. House of Representatives to establish a national mesothelioma patient registry.  The ‘Mary Jo Lawyer Spano Mesothelioma Patient Registry Act of 2015’ is district-focused legislation named in honor of Mary Jo Lawyer Spano, a Central New York woman who late last year lost her four-year battle with mesothelioma, an asbestos-related form of cancer that affects the lining the lungs, chest, heart, and abdomen. Spano’s sister, Meg Meccariello, who also suffers from mesothelioma, and mother, Elizabeth Lawyer, met with Rep. Katko early this Congress to advocate for the development of a National Mesothelioma Patient Registry.“Unlike many chronic and rare diseases, there is currently no national registry available for mesothelioma patients,” said Rep. John Katko. “These registries collect and consolidate information about individuals who suffer from the disease and provide health care professionals, researchers, and patients with the ability to search information about diagnosis, as well as track disease trends, risk-factors, and treatment availability.”

Spano’s father, Charles Lawyer, worked for an elevator company where he was exposed to asbestos and developed mesothelioma.  Sadly, Lawyer’s family was also exposed to asbestos fibers from his body and clothing.  Meccariello, a former nurse educator at St. Joseph’s Hospital Health Center in Syracuse, continues to receive chemotherapy and hopes that the creation of a national registry will give patients nationwide the hope to work towards a “new” normal way of life, even while recovering from mesothelioma.

Katko’s legislation creates the National Mesothelioma Patient Registry, a self-enrolled public database, which will collect and house information about individuals living with mesothelioma.

[Article continues at original source]

Source: KATKO INTRODUCES BIPARTISAN LEGISLATION TO CREATE NATIONAL MESOTHELIOMA PATIENT REGISTRY | Congressman John Katko


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Panel Hears Debate on Punitive Damages in Asbestos Cases

Leaders of the asbestos litigation bar were peppered with questions Wednesday by an Appellate Division, First Department, panel in a case testing whether punitive damages can be argued before New York City’s special asbestos court.

Such claims were effectively outlawed by a 1996 amendment to the case management order created to expedite cases in the New York City Asbestos Litigation court, known as “NYCAL.”

The “no punitives” order was issued by Justice Helen Freedman, who led NYCAL from 1987 to 2008 before being appointed to the First Department.

Freedman, who retired in October, attended Wednesday’s hearing and occasionally interjected as her former colleagues debated the wisdom of amending her order.

Freedman’s replacement as head of the NYCAL court, Justice Shirley Klein Heitler, granted a motion by the plaintiffs’ bar to allow punitive damages claims in April 2014. Heitler said she could not ignore “the fact that victims of asbestos exposure are permitted to apply for punitive damages in every New York state court except this one. I, for one, cannot justify a situation in which an asbestos plaintiff is permitted to apply for punitive damages in Buffalo but not in this court” (NYLJ, March 2).

The defense bar has appealed her ruling, asserting that “the reasons for the agreement struck by plaintiffs’ and defense counsel and approved by Justice Freedman to defer punitive damages claims are even stronger today than they were 18 years ago.”

[Article continues at original source]

Source: Panel Hears Debate on Punitive Damages in Asbestos Cases | Law.com

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Asbestos-related cancer treatment breakthrough leaves Australian researchers optimistic

Australian researchers are cautiously optimistic after using nanocells to achieve what could be one of the most significant breakthroughs in asbestos-related cancer treatment in a decade.

Scientists from the Chris O’Brien Lifehouse Centre have published a case report of a patient whose mesothelioma has almost entirely disappeared.

Bradley Selmon was one of ten patients in a phase-one clinical trial of a new treatment that used very small genes known as microRNA to inhibit tumour growth.

The genes were transported to the mesothelioma in his right lung using Australian-designed nanocells.

Associate Professor Glen Reid from the Asbestos Diseases Research Institute (ADRI) put the microRNA inside nanocells and said it was like using a Trojan horse.

[Article continues at original source]

Source: Asbestos-related cancer treatment breakthrough leaves Australian researchers optimistic – ABC News (Australian Broadcasting Corporation)


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Report on Top 10 mesothelioma research priorities published

The NIHR has published a new report today about setting future priorities for mesothelioma research. The report follows an NIHR-funded Priority Setting Partnership (PSP) set up by the James Lind Alliance to identify and prioritise future mesothelioma research topics.

Mesothelioma is a rare and often fatal form of cancer with very poor survival rates, most commonly associated with breathing in significant amounts of asbestos dust. Research into mesothelioma has been highlighted as a priority by the NIHR.

The partnership brought patients, carers and health professionals together in an extensive consultation to help identify and prioritise the unanswered questions that concern them most about the disease.

You can read the report at www.psp.nihr.ac.uk/mesothelioma/results.


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

‘Imagine your lungs being coated in cement’

Rick Luzaich took the job out of high school — two years grinding parts in a Minnesota machine shop. A career in business management and other white-collar jobs followed, his days as a grinder fading into the distance.

What he didn’t know then or for many years afterward was just what he’d inhaled during that short stint doing blue-collar work.

He was in his late 50s, living outside Minneapolis, when he began feeling short-winded and ill. Heart trouble, doctors thought at first. Last year, he and wife Jennifer found out what really ailed him: mesothelioma, an aggressive cancer triggered by exposure to asbestos….

[Article continues at original source]

Source: ‘Imagine your lungs being coated in cement’


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Manufacturer of Asbestos-Free Product May Still Be Liable for Asbestos Related Injuries

In Sherman v. Hennessy Industries, Inc. (No. B252566, filed June 18, 2015), the Court of Appeal, Second District, reversed a trial court’s grant of summary judgment in favor of a manufacturer of a brake grinding machine. The Court cited an exception to the general rule that manufacturers may not be held liable, under a strict products liability theory, where the plaintiff’s injuries arise from other products that are used in conjunction with the defendant’s product.

Plaintiff and appellant, Michael Sherman, was an automobile mechanic from 1962 to 1977. Mr. Sherman alleged that during this period he used an arcing machine, which abraded brake linings by means of sand paper moving at high speeds. Sherman alleged the machine released asbestos dust, which he then brought home, exposing his wife Debra Sherman to asbestos. Ms. Sherman developed mesothelioma and passed away from exposure to the asbestos dust carried home by her husband….

[Article continues at original source]

Source: Manufacturer of Asbestos-Free Product May Still Be Liable for Asbestos Related Injuries


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Compensation upheld for Perth man who died after asbestos exposure at SA BHP shipyard

The lawyer representing a man who died from an asbestos-related illness says a High Court decision upholding his compensation sets an important legal precedent for former BHP Billiton workers who contract mesothelioma.

The Sydney court rejected the company’s bid to appeal against a compensation claim awarded to Perth man Willem van Soest who was exposed to asbestos during an 11-week stint as a painter and docker at South Australia’s Whyalla Shipyard in 1962.

At the time he was working near laggers who were installing asbestos insulation around pipes and boilers.

Mr van Soest was diagnosed with mesothelioma in 2012 and died the next year aged 74….

[Article continues at original source]

Source: Compensation upheld for Perth man who died after asbestos exposure at SA BHP shipyard


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, NC 28403
Tel: (800) 426-9535
[email protected]
Disclaimer and Copyright