Radiotherapy to intervention sites in mesothelioma: no more?

Malignant pleural mesothelioma is a tumour with a dismal prognosis, and its incidence is increasing worldwide as a result of widespread exposure to asbestos. Because of the pattern of tumour growth, the ipsilateral chest wall is often involved. Moreover, histological diagnosis is usually obtained by pleural biopsy, via video-assisted thoracoscopic surgery or other invasive procedures, which can result in tumour seeding at the site of the intervention. Chest wall involvement, including procedure-tract metastases, can lead to severe symptoms, mostly pain. Accordingly, local control in malignant pleural mesothelioma is a major challenge.

Radiotherapy has been widely used in the past decades in the treatment of patients with malignant pleural mesothelioma, as a part of a multimodality therapy for early-stage disease,1, 2 in the palliation of pain,3 and in the prophylaxis of track-site recurrence….

[Article continues at original source]

Source: Radiotherapy to intervention sites in mesothelioma: no more? – The Lancet Oncology


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Judge Dismisses Union Carbide in Miami Mesothelioma Case

Asbestos mass tort litigation may have been around for more than four decades, but a Miami federal judge found room for novel decisions.

U.S. District Judge Beth Bloom corrected herself twice on jurisdiction in a case filed against Union Carbide Corp. The orders dealt in part with a 2014 U.S. Supreme Court decision still in the infancy of its interpretation across the country.

The case before Bloom was filed last year by James Waite, who claimed he developed mesothelioma from exposure to asbestos in Massachusetts starting in the 1940s. Waite has lived in Florida with his wife Sandra, a co-plaintiff, since the late 1970s and was diagnosed with mesothelioma last year. He does not allege any Union Carbide asbestos exposure in Florida.

Waite’s attorneys said he was exposed to asbestos as a landlord while renovating rental apartments using drywall joint compound that contained Union Carbide asbestos and during brake and clutch repairs.

Source: Judge Dismisses Union Carbide in Miami Mesothelioma Case | Daily Business Review

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Abstract

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.

[Article continues at original source]

(Source: http://www.nature.com/articles/srep22850)

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

‘Take Home’ Asbestos Death Nets $7M Verdict

BATON ROUGE (CN) – A Louisiana trial judge awarded $7 million to the surviving family members of a woman who died of cancer after years of laundering her husband’s asbestos-tainted clothes .

Myra Williams died from mesothelioma, a disease caused exclusively by exposure to asbestos after years of contact with the material at home through handling her husband’s work clothes. Myra’s husband, Jimmy Williams, worked around asbestos at his job for Placid Oil Co., court documents say.

As part of his job at Placid Oil, according to the documents, Jimmy Williams was required to crawl over equipment insulated with asbestos.

“This caused asbestos dust and fibers to accumulate on his clothing, which he wore home on a daily basis to be laundered by Myra Williams,” Judge Lala Sylvester’s ruling said.

[Article continues at original source]

Source: ‘Take Home’ Asbestos Death Nets $7M Verdict

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Mesothelioma victim’s family wins asbestos award

A federal jury in Arizona has awarded a total of $17 million to the surviving spouse and children of a worker who died of mesothelioma caused by exposure to asbestos.

In December 2012, George Coulbourn filed a product liability action in Mohave County Superior Court. He alleged he was exposed to companies’ asbestos-containing products and/or machinery while working as a machinist for the Norfolk Naval Shipyard in Portsmouth, Virginia, from 1959 to 1966, court records show.

After Mr. Coulbourn died of mesothelioma in August 2013, his spouse and children amended his complaint and brought a wrongful death action, records show.

[Article continues at original source]

Source: Mesothelioma victim’s family wins asbestos award – Business Insurance

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Age should not preclude patients with malignant pleural mesothelioma from surgery

 Age alone should not be an exclusion criterion for extended pleurectomy decortication among elderly patients with malignant pleural mesothelioma, according to a review of prospectively collected data presented at the European Lung Cancer Conference.

However, a thorough presurgical assessment of nodal disease and fitness is necessary before older patients undergo adjuvant chemotherapy, according to the researchers. These factors appeared to have a greater negative impact in older patients than younger patients.

Extended pleurectomy decortication (EPD) has been preferred over extrapleural pneumonectomy for patients with malignant pleural mesothelioma who meet strict criteria, according to the researchers.

Although EPD has shown feasibility for elderly patients, debate continues regarding the efficacy of this procedure for older patients.

Annabel J. Sharkey, MBChB , a thoracic surgeon at Glenfield Hospital in Leicester, United Kingdom, and colleagues sought to review data regarding EPD safety and efficacy for elderly patients.

[Article continues at original source]

Source: Age should not preclude patients with malignant pleural mesothelioma from surgery

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

After 16 Years, Pittsburgh Corning Exits Asbestos-Related Bankruptcy

After more than 16 years under court protection, Pittsburgh Corning Corp., the joint venture between PPG Industries Inc. and Corning Inc., emerged from its asbestos-related bankruptcy Wednesday.

The Pittsburgh Corning plan channels claims against the company’s non-bankrupt parents to a $3.5 billion trust that was set up under the plan to absorb asbestos liabilities. The trust, one of the country’s largest, is being funded by PPG, Corning and their insurers.

Pittsburgh Corning, a maker of glass-based insulation materials used in construction and oil and gas pipelines, spent the first five years in bankruptcy on protecting and preserving its assets.

“When it became apparent that Pittsburgh Corning’s time in bankruptcy was going to be extended, our focus expanded to include strategic actions designed to reinvent our business,” said James R. Kane, the company’s chief executive.

Pittsburgh Corning is one of many large companies attempting to use bankruptcy to survive an onslaught of claims for asbestos damage. The bankruptcy code allows companies to set up trust funds to pay claims, insulating their future operating funds from potential liabilities.

[Article continues at original source]

Source: After 16 Years, Pittsburgh Corning Exits Asbestos-Related Bankruptcy

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Immunotherapy With Live Bacterium Improves Response Rate in Malignant Pleural Mesothelioma

ELCC 2016 Press Release: Immunotherapy With Live Bacterium Improves Response Rate in Malignant Pleural Mesothelioma

Date: 14 Apr 2016Topic: Lung and other thoracic tumours / Cancer Immunology and Immunotherapy

GENEVA, Switzerland – Immunotherapy with a live bacterium combined with chemotherapy demonstrated more than 90% disease control and 59% response rate in patients with malignant pleural mesothelioma (MPM), according to the results of a phase Ib trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.

“Malignant pleural mesothelioma is a cancer of the lining of the lung and is rare but difficult to treat,” said Prof Thierry Jahan, professor of medicine at the UCSF Helen Diller Family Comprehensive Cancer Center in San Francisco, US. “Standard of care treatment with pemetrexed and platinum compound chemotherapy gets a 30% response rate but a modest impact on survival. So there is a clear unmet need in targeting this specific population.

”Patients with MPM strongly express the mesothelin antigen in the tumour. CRS-207 is a live, attenuated Listeria monocytogenes bacterium that contains two gene deletions to diminish its pathogenicity and has also been engineered to express mesothelin.“

In our early studies, CRS-207 induced an anti-mesothelin response and cellular tumour specific immunity in patients with mesothelin expressing tumours,” said Jahan. “We also have data suggesting that this immunotherapy works synergistically with chemotherapy, so testing the effect of this immune targeting agent with chemotherapy was a natural step.”

[Article continues at original source]

Source: ELCC 2016 Press Release: Immunotherapy With Live Bacterium Improves Response Rate in Malignant Pleural Mesothelioma | ESMO

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Justices Consider Any-Exposure Theory

As the Pennsylvania Supreme Court heard arguments Wednesday in Rost v. Ford Motor over use of the “any exposure” theory by an expert witness in an asbestos trial, the discussion dipped into the territory of “magic words” and hypothetical questions, but one question remained at the core of the conversation: Did Dr. Arthur Frank lay out a sufficient basis for his testimony that Richard Rost’s exposure to Ford Motor Co. products was a causative factor in his developing mesothelioma?

According to Robert L. Byer of Duane Morris, arguing on behalf of Ford, Frank responded to a hypothetical proposed to him by indicating that any exposure to asbestos can cause mesothelioma. In attempting to further explain his opinion, Byer said, Frank reverted to a theory of cumulative exposure that Byer said is indistinguishable from the any-exposure theory the Supreme Court has said cannot be introduced.

Steven Cooperstein of Brookman, Rosenberg, Brown & Sandler, arguing for Rost, contended that Frank at no time said “each and every breath” is substantially causative. Frank testified that “‘any exposure that can be documented would … play a role and be causative,'” according to Rost’s brief, but Cooperstein said that isn’t the same as opining that any exposure is causative.

“The subtlety of your distinction is lost on me,” Justice Max Baer said.

[Article continues at original source]

Source: Justices Consider Any-Exposure Theory, Asbestos Consolidation

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Cahill Gordon, BASF Can’t Escape Asbestos Fraud Suit

A federal judge in Newark has denied a motion by New York-based Cahill, Gordon & Reindel and two of its attorneys seeking to be dismissed from a putative class action suit claiming they conspired with a client to destroy and fabricate evidence in thousands of asbestos injury cases. The judge also denied motions to dismiss Cahill Gordon’s alleged accomplice in the fraud, BASF Catalysts, along with two former in-house lawyers for the company.

The plaintiffs sufficiently stated facts to support claims of fraudulent concealment, spoliation, fraud and civil conspiracy against the defendants. U.S. District Judge Jose Linares of the District of New Jersey said in an April 5 ruling in Williams v. BASF Catalysts Inc.. His ruling follows a decision by U.S. District Judge Stanley Chesler in 2012 dismissing the case in its entirety and a partial reversal of that decision in 2014 by the U.S. Court of Appeals for the Third Circuit.

Cahill Gordon faces the class action over its role in defending BASF in a series of asbestos exposure suits concerning products containing talc from a company-owned mine in Vermont. Internal testing indicated that the talc contained asbestos, but BASF maintained that the product was asbestos-free, according to court documents. When it was named in an asbestos injury suit in 1979, a BASF predecessor, Engelhard, retained Cahill Gordon. Testimony in that suit, identified in court papers as the Westfall case, revealed that multiple tests performed by Engelhard employees and third parties showed the company’s talc contained asbestos, court documents said.

The plaintiffs allege that after the first case was settled, with a confidentiality clause in the agreement, BASF scientist Glenn Hemstock circulated a memo directing company employees to purge all materials relating to the asbestos-containing talc. The plaintiffs also accuse Cahill Gordon and BASF of procuring false representations from company employees and outside experts, and including false or misleading information in court filings. The alleged scheme came to light in 2009, when a former BASF researcher testified that he knew the company’s talc contained asbestos and that the Vermont mine was shut down for that reason. Between 1984 and 2009, BASF and Cahill Gordon made misrepresentations to thousands of claimants in asbestos injury suits around the country, the plaintiffs claim.

[Article continues at original source]

Source: Cahill Gordon, BASF Can’t Escape Asbestos Fraud Suit | New Jersey Law Journal

 


 Mesothelioma, Asbestos, and Legal Compensation: Basic Facts

Asbestos-Mesothelioma Case Evaluation Form
Free.  Confidential.  No Obligation.

Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, NC 28403
Tel: (800) 426-9535
[email protected]
Disclaimer and Copyright