Dr. Thierry Jahan on the CRS-207 Vaccine in Mesothelioma [interview video]

Thierry M. Jahan, MD, a clinical professor in the Department of Medicine at the University of California San Francisco Helen Diller Family Comprehensive Cancer Center, discusses a phase Ib trial of CRS-207 in malignant pleural mesothelioma (MPM).

CRS-207 is a live-attenuated, double-deleted Listeria monocytogene engineered to express the tumor-associated antigen mesothelin. In the the phase Ib it was administered with chemotherapy to 38 patients with MPM. Of 34 evaluable patients, 59% (n = 20) had partial response posttreatment and 35% (n = 12) had stable disease, for an overall disease-control rate 94%.

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Source: Dr. Thierry Jahan on the CRS-207 Vaccine in Mesothelioma

 


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Surgery Improves Quality of Life for Patients With Malignant Pleural Mesothelioma

Undergoing pleurectomy and decortication (PD) for malignant pleural mesothelioma (MPM) generally leads to improved quality of life after the surgery. These findings were presented at the 2016 American Society of Clinical Oncology Annual Meeting.

Many patients with malignant pleural mesothelioma avoid the operation because they fear it will degrade their quality of life. The disease is caused by environmental factors such as asbestos exposure and by a genetic predisposition to the cancer.

Malignant pleural mesothelioma develops in the pleura, the thin layer of tissue surrounding the lungs. As the tumor grows, it restricts the lungs, typically causing shortness of breath, fatigue, weight loss, and/or chest discomfort and pain. Pleurectomy and decortication involves removal of the pleura. Although the procedure cannot cure mesothelioma, it can help control the buildup of fluid, improve breathing, and lessen cancer pain.

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Source: Surgery Improves Quality of Life for Patients With Malignant Pleural Mesothelioma

 


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Teacher developed cancer from asbestos

The case of a former Queensland science teacher who was diagnosed with cancer after working with equipment made from asbestos is not isolated, his lawyers say.

The 69-year-old, who has requested not to be named, taught in a Toowoomba school for over a decade in the 1970s and 80s.

A former science teacher has been diagnosed with mesothelioma.
A former science teacher has been diagnosed with mesothelioma. Photo: Jason South

He said he spent each day “inadvertently breathing in the ticking time bomb” because Bunsen burner safety mats, which were made from asbestos, were slowly disintegrating as they were moved around the classrooms.

He was diagnosed with mesothelioma in March this year.

“Prior to my diagnosis I was very fit and healthy,” the father of two and grandfather of four said.

“It came as a huge shock to me and my family to be told I had asbestos cancer after over 35 years as a teacher.”

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Source: Teacher developed cancer from asbestos

 


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Radiotherapy to intervention sites in mesothelioma: no more?

Malignant pleural mesothelioma is a tumour with a dismal prognosis, and its incidence is increasing worldwide as a result of widespread exposure to asbestos. Because of the pattern of tumour growth, the ipsilateral chest wall is often involved. Moreover, histological diagnosis is usually obtained by pleural biopsy, via video-assisted thoracoscopic surgery or other invasive procedures, which can result in tumour seeding at the site of the intervention. Chest wall involvement, including procedure-tract metastases, can lead to severe symptoms, mostly pain. Accordingly, local control in malignant pleural mesothelioma is a major challenge.

Radiotherapy has been widely used in the past decades in the treatment of patients with malignant pleural mesothelioma, as a part of a multimodality therapy for early-stage disease,1, 2 in the palliation of pain,3 and in the prophylaxis of track-site recurrence….

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Source: Radiotherapy to intervention sites in mesothelioma: no more? – The Lancet Oncology


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Judge Dismisses Union Carbide in Miami Mesothelioma Case

Asbestos mass tort litigation may have been around for more than four decades, but a Miami federal judge found room for novel decisions.

U.S. District Judge Beth Bloom corrected herself twice on jurisdiction in a case filed against Union Carbide Corp. The orders dealt in part with a 2014 U.S. Supreme Court decision still in the infancy of its interpretation across the country.

The case before Bloom was filed last year by James Waite, who claimed he developed mesothelioma from exposure to asbestos in Massachusetts starting in the 1940s. Waite has lived in Florida with his wife Sandra, a co-plaintiff, since the late 1970s and was diagnosed with mesothelioma last year. He does not allege any Union Carbide asbestos exposure in Florida.

Waite’s attorneys said he was exposed to asbestos as a landlord while renovating rental apartments using drywall joint compound that contained Union Carbide asbestos and during brake and clutch repairs.

Source: Judge Dismisses Union Carbide in Miami Mesothelioma Case | Daily Business Review

 


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Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Abstract

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.

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(Source: http://www.nature.com/articles/srep22850)

 


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‘Take Home’ Asbestos Death Nets $7M Verdict

BATON ROUGE (CN) – A Louisiana trial judge awarded $7 million to the surviving family members of a woman who died of cancer after years of laundering her husband’s asbestos-tainted clothes .

Myra Williams died from mesothelioma, a disease caused exclusively by exposure to asbestos after years of contact with the material at home through handling her husband’s work clothes. Myra’s husband, Jimmy Williams, worked around asbestos at his job for Placid Oil Co., court documents say.

As part of his job at Placid Oil, according to the documents, Jimmy Williams was required to crawl over equipment insulated with asbestos.

“This caused asbestos dust and fibers to accumulate on his clothing, which he wore home on a daily basis to be laundered by Myra Williams,” Judge Lala Sylvester’s ruling said.

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Source: ‘Take Home’ Asbestos Death Nets $7M Verdict

 


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Mesothelioma victim’s family wins asbestos award

A federal jury in Arizona has awarded a total of $17 million to the surviving spouse and children of a worker who died of mesothelioma caused by exposure to asbestos.

In December 2012, George Coulbourn filed a product liability action in Mohave County Superior Court. He alleged he was exposed to companies’ asbestos-containing products and/or machinery while working as a machinist for the Norfolk Naval Shipyard in Portsmouth, Virginia, from 1959 to 1966, court records show.

After Mr. Coulbourn died of mesothelioma in August 2013, his spouse and children amended his complaint and brought a wrongful death action, records show.

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Source: Mesothelioma victim’s family wins asbestos award – Business Insurance

 


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Age should not preclude patients with malignant pleural mesothelioma from surgery

 Age alone should not be an exclusion criterion for extended pleurectomy decortication among elderly patients with malignant pleural mesothelioma, according to a review of prospectively collected data presented at the European Lung Cancer Conference.

However, a thorough presurgical assessment of nodal disease and fitness is necessary before older patients undergo adjuvant chemotherapy, according to the researchers. These factors appeared to have a greater negative impact in older patients than younger patients.

Extended pleurectomy decortication (EPD) has been preferred over extrapleural pneumonectomy for patients with malignant pleural mesothelioma who meet strict criteria, according to the researchers.

Although EPD has shown feasibility for elderly patients, debate continues regarding the efficacy of this procedure for older patients.

Annabel J. Sharkey, MBChB , a thoracic surgeon at Glenfield Hospital in Leicester, United Kingdom, and colleagues sought to review data regarding EPD safety and efficacy for elderly patients.

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Source: Age should not preclude patients with malignant pleural mesothelioma from surgery

 


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After 16 Years, Pittsburgh Corning Exits Asbestos-Related Bankruptcy

After more than 16 years under court protection, Pittsburgh Corning Corp., the joint venture between PPG Industries Inc. and Corning Inc., emerged from its asbestos-related bankruptcy Wednesday.

The Pittsburgh Corning plan channels claims against the company’s non-bankrupt parents to a $3.5 billion trust that was set up under the plan to absorb asbestos liabilities. The trust, one of the country’s largest, is being funded by PPG, Corning and their insurers.

Pittsburgh Corning, a maker of glass-based insulation materials used in construction and oil and gas pipelines, spent the first five years in bankruptcy on protecting and preserving its assets.

“When it became apparent that Pittsburgh Corning’s time in bankruptcy was going to be extended, our focus expanded to include strategic actions designed to reinvent our business,” said James R. Kane, the company’s chief executive.

Pittsburgh Corning is one of many large companies attempting to use bankruptcy to survive an onslaught of claims for asbestos damage. The bankruptcy code allows companies to set up trust funds to pay claims, insulating their future operating funds from potential liabilities.

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Source: After 16 Years, Pittsburgh Corning Exits Asbestos-Related Bankruptcy

 


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